POS1170 EXPLORING SUBCLINICAL MICROVASCULAR CHANGES IN ANCA-VASCULITIDES: THE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND NAILFOLD CAPILLAROSCOPY IN THE EVALUATION OF DISEASE-RELATED DAMAGE

Background Both cardiovascular and complement-mediated disorders might lead to microvascular damage in anti-neutrophil cytoplasm autoantibodies (ANCA)-associated vasculitides (AAV). No evidence of subclinical retinal abnormalities neither their potential correlation with capillaroscopy anomalies has been reported eosinophilic granulomatosis polyangiitis (EGPA), (GPA), microscopic (MPA). Objectives We aimed at investigating by analyzing nailfold capillary changes an AAV cohort. Retinal plexi were investigated using optical coherence tomography angiography (OCT-A), while videocapillaroscopy (NVC). Potential correlations between OCT-A both disease periungual capillaries change also explored. Methods A monocentric observational study was conducted on consecutive AAV. Main inclusion criteria a defined diagnosis EGPA/GPA/MPA accordance International Criteria, age ≥18 ≤ 75 yrs, intraocular pressure (IOP) <21 mmHg Goldmann, best-corrected-visual-acuity (BCVA) ≥ 0,5 logMAR, no ophthalmological and/or systemic or treatment known involvement. Disease activity assessed Birmingham Vasculitis Activity Score (BVAS), Damage Index (VDI), poorer prognosis the Five Factor (FFS). Moreover, OSDI MIDAS questionnaires have administered. Quantitative analysis vessel density (VD) performed superficial (SCP) deep (DCP) for all subjects. For completeness, structural thickness OCT-scans. Figures detailed from NVC patients. Results From 47 patients referring Rheumatologic Clinic, 23 who met included compared 20 age/sex-matched healthy subjects (HC) (Table 1). In AAV, BVAS correlated directly VDI (P=0.001) FFS (P=0.01) it inversely related duration (P=0.01). total 46 eyes analyzed. VD whole (SWD) parafoveal (SPFD) significantly decreased HC (P=0.02 P=0.01, respectively, Figure 1A-B). Furthermore, (DWD) (DPFD) strongly reduced than (P ≤0.0001 both, 1C-D). patients, significant inverse emerged OCTA-VD (parafoveal, P=0.03) (whole, P=0.003, P=0.02). The measured OCT-scans similar HC. At examination we found non-specific pattern 82% Common pericapillary edema (73%), tortuosity (65%), rare cases ectasias hemorrhages resulted (0.8%). meandering nor empty dermal papillae observed. Correlations not described. Conclusion Subclinical occur correlate disease-related damage. this context, can represent useful tool early detection vascular present NVC, whose clinical relevance requires further studies. Table 1. (n=23) GPA, N/% 5/22 EGPA, 9/39 MPA, Age (yrs, mean ± SD) 60.9 8.7 9.6 9.1 ENT, 15/65 Kidney, 4/17 Heart, Lung, 21/91 Skin, 6/26 Joint, Peripheral Nervous System, 13/57 ANCA positivity, 16/69.6 (mean 3.3 2.5 4.5 1.5 0.3 0.4 REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.